Version 5.4
Homo sapiens Protein: LRP3
Summary
InnateDB Protein IDBP-42554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP3
Protein Name low density lipoprotein receptor-related protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253193
InnateDB Gene IDBG-42552 (LRP3)
Protein Structure
UniProt Annotation
Function Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte. {ECO:0000269PubMed:9693042}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005905 coated pit
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00431
PF00057
PRINTS PR00261
PIRSF
SMART SM00042
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75074
PhosphoSite PhosphoSite-O75074
TrEMBL V9GYG8
UniProt Splice Variant
Entrez Gene 4037
UniGene Hs.515340
RefSeq NP_002324
HUGO HGNC:6695
OMIM 603159
CCDS CCDS12430
HPRD 04406
IMGT
EMBL AB009462 AC008738 AK074751 AK296536 BC007408
GenPept AAH07408 BAA32330 BAG51998 BAG59164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca