Version 5.4
Homo sapiens Protein: SLC7A10
Summary
InnateDB Protein IDBP-42598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A10
Protein Name solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253188
InnateDB Gene IDBG-42596 (SLC7A10)
Protein Structure
UniProt Annotation
Function Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. {ECO:0000269PubMed:10863037}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. {ECO:0000269PubMed:10863037}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0007596 blood coagulation
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0042941 D-alanine transport
GO:0042942 D-serine transport
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002293 Amino acid/polyamine transporter I
IPR004841 Amino acid permease/ SLC12A domain
PFAM PF13520
PF00324
PRINTS
PIRSF PIRSF006060
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NS82
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56301
UniGene Hs.58679
RefSeq NP_062823
HUGO HGNC:11058
OMIM 607959
CCDS CCDS12431
HPRD 12137
IMGT
EMBL AB037670 AF340155 AF340156 AF340157 AF340158 AF340159 AF340160 AF340161 AF340162 AF340163 AF340164 AF340165 AJ277731 AK316594 BC035627
GenPept AAH35627 AAK93960 BAB03213 BAG38181 CAC81900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca