InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABARAPL2

Summary

InnateDB Protein

IDBP-42627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABARAPL2

Protein Name

GABA(A) receptor-associated protein-like 2

Synonyms

ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000037243

InnateDB Gene

IDBG-42625 (GABARAPL2)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000250, ECO:0000269PubMed:20418806, ECO:0000269PubMed:23209295}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000269PubMed:12507496, ECO:0000269PubMed:15169837, ECO:0000269PubMed:17580304, ECO:0000269PubMed:19056683, ECO:0000269PubMed:22311637}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. {ECO:0000269PubMed:11146101, ECO:0000269PubMed:11414770}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	90 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0048487	beta-tubulin binding
GO:0050811	GABA receptor binding
GO:0051117	ATPase binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006891	intra-Golgi vesicle-mediated transport
GO:0006914	autophagy
GO:0015031	protein transport
GO:0032781	positive regulation of ATPase activity
GO:1901799	negative regulation of proteasomal protein catabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0000421	autophagic vacuole membrane
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0031410	cytoplasmic vesicle