InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHROOM2

Summary

InnateDB Protein

IDBP-42700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHROOM2

Protein Name

shroom family member 2

Synonyms

APXL; HSAPXL;

Species

Homo sapiens

Ensembl Protein

ENSP00000370299

InnateDB Gene

IDBG-42698 (SHROOM2)

Protein Structure

UniProt Annotation

Function

May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with cortical F-actin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0015280	ligand-gated sodium channel activity
GO:0019904	protein domain specific binding
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0002089	lens morphogenesis in camera-type eye
GO:0007420	brain development
GO:0008057	eye pigment granule organization
GO:0016477	cell migration
GO:0030835	negative regulation of actin filament depolymerization
GO:0032401	establishment of melanosome localization
GO:0032438	melanosome organization
GO:0035725	sodium ion transmembrane transport
GO:0043010	camera-type eye development
GO:0043482	cellular pigment accumulation
GO:0043583	ear development
GO:0045176	apical protein localization
GO:0045217	cell-cell junction maintenance
GO:0048593	camera-type eye morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0016324	apical plasma membrane
GO:0030864	cortical actin cytoskeleton
GO:0031941	filamentous actin
GO:0043025	neuronal cell body
GO:0043296	apical junction complex
GO:0070062	extracellular vesicular exosome