InnateDB Protein
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IDBP-4273.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCN2
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Protein Name
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transcobalamin II
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Synonyms
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D22S676; D22S750; II; TC; TC II; TC-2; TC2; TCII;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000215838
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InnateDB Gene
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IDBG-4271 (TCN2)
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Protein Structure
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Function |
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
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Subcellular Localization |
Secreted.
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Disease Associations |
Transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]: Results in various forms of anemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002157
Cobalamin (vitamin B12)-binding transporter, eukaryotic
IPR008930
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
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PFAM |
PF01122
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P20062
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6948
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UniGene |
|
RefSeq |
NP_000346
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HUGO |
HGNC:11653
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OMIM |
613441
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CCDS |
CCDS13881
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HPRD |
02037
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IMGT |
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EMBL |
AC005006
AF047576
BC001176
BC011239
CR456591
L02647
L02648
M60396
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GenPept |
AAA61054
AAA61056
AAA61057
AAC05491
AAH01176
AAH11239
CAG30477
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