InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TERF2IP

Summary

InnateDB Protein

IDBP-42785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TERF2IP

Protein Name

telomeric repeat binding factor 2, interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300086

InnateDB Gene

IDBG-42783 (TERF2IP)

Protein Structure

UniProt Annotation

Function

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269PubMed:16166375, ECO:0000269PubMed:19763083}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 163 experimentally validated interaction(s) in this database.

Experimentally validated
Total	163 [view]
Protein-Protein	162 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000723	telomere maintenance
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007004	telomere maintenance via telomerase
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0010833	telomere maintenance via telomere lengthening
GO:0031848	protection from non-homologous end joining at telomere
GO:0032205	negative regulation of telomere maintenance
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048239	negative regulation of DNA recombination at telomere
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070198	protein localization to chromosome, telomeric region

Cellular Component

GO:0000228	nuclear chromosome
GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0030870	Mre11 complex