Homo sapiens Protein: CNTNAP4
Summary
InnateDB Protein IDBP-42812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTNAP4
Protein Name contactin associated protein-like 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000306893
InnateDB Gene IDBG-42808 (CNTNAP4)
Protein Structure
UniProt Annotation
Function Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Specifically present within the presynaptic compartment of synapses. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00754
PF00008
PF00054
PF02210
PF00147
PRINTS
PIRSF
SMART SM00231
SM00181
SM00210
SM00282
SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9C0A0
TrEMBL H3BPC8
UniProt Splice Variant
Entrez Gene 85445
UniGene Hs.461389
RefSeq
HUGO HGNC:18747
OMIM 610518
CCDS
HPRD 13079
IMGT
EMBL AC106741 AC108125
GenPept