InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF3A

Summary

InnateDB Protein

IDBP-42866.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF3A

Protein Name

kinesin family member 3A

Synonyms

FLA10; KLP-20;

Species

Homo sapiens

Ensembl Protein

ENSP00000368020

InnateDB Gene

IDBG-42864 (KIF3A)

Protein Structure

UniProt Annotation

Function

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0030507	spectrin binding

Biological Process

GO:0006996	organelle organization
GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042384	cilium assembly
GO:0061024	membrane organization
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0005813	centrosome
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0016939	kinesin II complex
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium