InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCN4

Summary

InnateDB Protein

IDBP-42907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCN4

Protein Name

chloride channel 4

Synonyms

ClC-4; ClC-4A; CLC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000370213

InnateDB Gene

IDBG-42905 (CLCN4)

Protein Structure

UniProt Annotation

Function

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. {ECO:0000269PubMed:18063579}.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundant in skeletal muscle and also detectable in brain and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity

Biological Process

GO:0006810	transport
GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane