Version 5.4
Homo sapiens Protein: THOC7
Summary
InnateDB Protein IDBP-42959.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THOC7
Protein Name THO complex 7 homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295899
InnateDB Gene IDBG-42957 (THOC7)
Protein Structure
UniProt Annotation
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269PubMed:15833825, ECO:0000269PubMed:15998806, ECO:0000269PubMed:17190602, ECO:0000269PubMed:18974867, ECO:0000269PubMed:23222130}.
Subcellular Localization Cytoplasm. Nucleus. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0046784 intronless viral mRNA export from host nucleus
Cellular Component
GO:0000346 transcription export complex
GO:0000347 THO complex
GO:0000445 THO complex part of transcription export complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR008501 THO complex subunit 7/Mft1
PFAM PF05615
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6I9Y2
PhosphoSite PhosphoSite-Q6I9Y2
TrEMBL A0A024R341
UniProt Splice Variant
Entrez Gene 80145
UniGene
RefSeq NP_079351
HUGO HGNC:29874
OMIM 611965
CCDS CCDS2900
HPRD 17632
IMGT
EMBL AC104162 AK027098 BC020599 BC065012 CH471055 CR457373
GenPept AAH20599 AAH65012 BAB15656 CAG33654 EAW65418 EAW65419 EAW65420 EAW65421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca