InnateDB Protein
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IDBP-43009.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MEMO1
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Protein Name
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mediator of cell motility 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295065
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InnateDB Gene
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IDBG-43005 (MEMO1)
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Protein Structure
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Function |
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269PubMed:15156151, ECO:0000269PubMed:20937854}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0032886
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regulation of microtubule-based process
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Cellular Component |
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PDB ID |
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InterPro |
IPR002737
MEMO1 family
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PFAM |
PF01875
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y316
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PhosphoSite |
PhosphoSite-Q9Y316
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TrEMBL |
C9JSD7
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UniProt Splice Variant |
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Entrez Gene |
51072
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UniGene |
Hs.645042
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RefSeq |
NP_057039
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HUGO |
HGNC:14014
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OMIM |
611786
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CCDS |
CCDS1776
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HPRD |
12814
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IMGT |
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EMBL |
AB041018
AB041019
AF132961
AF363446
AF529368
AK297128
AL121652
AL121655
BC018733
BC070046
BC094681
CH471053
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GenPept |
AAD27736
AAH18733
AAH70046
AAH94681
AAL34462
AAQ09602
BAD74066
BAD74067
BAG59632
EAX00467
EAX00469
EAX00470
EAX00472
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