Version 5.4
Homo sapiens Protein: FNIP2
Summary
InnateDB Protein IDBP-43032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNIP2
Protein Name folliculin interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264433
InnateDB Gene IDBG-43030 (FNIP2)
Protein Structure
UniProt Annotation
Function May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000250, ECO:0000269PubMed:18403135, ECO:0000269PubMed:18663353}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18403135, ECO:0000269PubMed:18663353, ECO:0000269PubMed:19137017}. Note=Colocalizes with FLCN in the cytoplasm.
Disease Associations
Tissue Specificity Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney. {ECO:0000269PubMed:18403135, ECO:0000269PubMed:18663353}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001932 regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0033138 positive regulation of peptidyl-serine phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P278
PhosphoSite PhosphoSite-Q9P278
TrEMBL
UniProt Splice Variant
Entrez Gene 57600
UniGene Hs.731810
RefSeq NP_065891
HUGO HGNC:29280
OMIM 612768
CCDS CCDS47155
HPRD
IMGT
EMBL AB040883 AK022968 BC007861 BC016638
GenPept AAH07861 AAH16638 BAA95974 BAB14338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca