Version 5.4
Homo sapiens Protein: DPY30
Summary
InnateDB Protein IDBP-43163.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPY30
Protein Name dpy-30 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295066
InnateDB Gene IDBG-43159 (DPY30)
Protein Structure
UniProt Annotation
Function As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. {ECO:0000269PubMed:19556245, ECO:0000269PubMed:19651892, ECO:0000269PubMed:21335234}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19651892}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:19651892}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016197 endosomal transport
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Protein Structure and Domains
PDB ID
InterPro IPR007858 Dpy-30 motif
PFAM PF05186
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C005
PhosphoSite PhosphoSite-Q9C005
TrEMBL
UniProt Splice Variant
Entrez Gene 84661
UniGene Hs.645042
RefSeq NP_115963
HUGO HGNC:24590
OMIM 612032
CCDS CCDS1777
HPRD 17434
IMGT
EMBL AF226998 BC015970 CH471053
GenPept AAH15970 AAK00640 EAX00463 EAX00466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca