Version 5.4
Homo sapiens Protein: NAF1
Summary
InnateDB Protein IDBP-43190.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAF1
Protein Name nuclear assembly factor 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274054
InnateDB Gene IDBG-43188 (NAF1)
Protein Structure
UniProt Annotation
Function RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269PubMed:16618814}.
Subcellular Localization Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007504 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
IPR009000 Translation protein, beta-barrel domain
PFAM PF04410
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HR8
PhosphoSite PhosphoSite-Q96HR8
TrEMBL
UniProt Splice Variant
Entrez Gene 92345
UniGene Hs.129095
RefSeq NP_612395
HUGO HGNC:25126
OMIM
CCDS CCDS3803
HPRD 10054
IMGT
EMBL AC022272 AK308601 BC008207 CH471056
GenPept AAH08207 EAX04843 EAX04844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca