InnateDB Protein
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IDBP-43262.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPI1
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Protein Name
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spleen focus forming virus (SFFV) proviral integration oncogene spi1
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Synonyms
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OF; PU.1; SFPI1; SPI-1; SPI-A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367799
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InnateDB Gene
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IDBG-43260 (SPI1)
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Protein Structure
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Function |
Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:23166356}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated |
Total |
105
[view]
|
Protein-Protein |
68
[view]
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Protein-DNA |
37
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
61 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000980
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RNA polymerase II distal enhancer sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001047
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core promoter binding
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GO:0001085
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RNA polymerase II transcription factor binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003705
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RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
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GO:0003723
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RNA binding
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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GO:0051525
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NFAT protein binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0043966
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histone H3 acetylation
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GO:0044027
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hypermethylation of CpG island
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GO:0045087
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innate immune response (InnateDB)
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GO:0045646
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regulation of erythrocyte differentiation
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GO:0045814
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negative regulation of gene expression, epigenetic
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0090241
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negative regulation of histone H4 acetylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000418
Ets domain
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PFAM |
PF00178
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PRINTS |
PR00454
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PIRSF |
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SMART |
SM00413
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TIGRFAMs |
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Modification |
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SwissProt |
P17947
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PhosphoSite |
PhosphoSite-P17947
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6688
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UniGene |
Hs.502511
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RefSeq |
NP_003111
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HUGO |
HGNC:11241
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OMIM |
165170
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CCDS |
CCDS7933
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HPRD |
01305
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IMGT |
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EMBL |
AC090559
AC090582
AL532058
X52056
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GenPept |
CAA36281
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