Version 5.4
Homo sapiens Protein: SLC25A26
Summary
InnateDB Protein IDBP-43526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A26
Protein Name solute carrier family 25, member 26
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000336801
InnateDB Gene IDBG-43522 (SLC25A26)
Protein Structure
UniProt Annotation
Function Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S- adenosylmethionine (SAM) into the mitochondria. {ECO:0000269PubMed:14674884}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:14674884}; Multi-pass membrane protein {ECO:0000269PubMed:14674884}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen. {ECO:0000269PubMed:14674884}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000095 S-adenosylmethionine transmembrane transporter activity
Biological Process
GO:0015805 S-adenosylmethionine transport
GO:1901962 S-adenosyl-L-methionine transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q70HW3
PhosphoSite PhosphoSite-Q70HW3
TrEMBL
UniProt Splice Variant
Entrez Gene 115286
UniGene Hs.648522
RefSeq NP_001158268
HUGO HGNC:20661
OMIM 611037
CCDS CCDS54604
HPRD 15357
IMGT
EMBL AJ580932 AK092495 AK096876 AK291873 BC003399 BC012852 CH471055
GenPept AAH12852 BAF84562 BAG52559 BAG53388 CAE45652 EAW65449 EAW65451

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca