Homo sapiens Protein: MORC2
Summary
InnateDB Protein IDBP-4353.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MORC2
Protein Name MORC family CW-type zinc finger 2
Synonyms ZCW3; ZCWCC1;
Species Homo sapiens
Ensembl Protein ENSP00000215862
InnateDB Gene IDBG-4351 (MORC2)
Protein Structure
UniProt Annotation
Function May act as a transcriptional repressor. Down-regulates CA9 expression. {ECO:0000269PubMed:20110259, ECO:0000269PubMed:20225202}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20225202}. Cytoplasm, cytosol {ECO:0000269PubMed:20225202}. Note=Mainly located in the nucleus.
Disease Associations
Tissue Specificity Highly expressed in smooth muscle, pancreas and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0030246 carbohydrate binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR008965 Carbohydrate-binding domain
IPR011124 Zinc finger, CW-type
PFAM PF02518
PF13581
PF07496
PRINTS
PIRSF
SMART SM00387
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6X9
PhosphoSite PhosphoSite-Q9Y6X9
TrEMBL
UniProt Splice Variant
Entrez Gene 22880
UniGene Hs.555918
RefSeq NP_055756
HUGO HGNC:23573
OMIM
CCDS CCDS33636
HPRD 11699
IMGT
EMBL AB020659 AC004542 AL133637 BC019257 BC136782 CH471095 CR456469
GenPept AAC12954 AAH19257 AAI36783 BAA74875 CAB63760 CAG30355 EAW59921