InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLHL2

Summary

InnateDB Protein

IDBP-43534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL2

Protein Name

kelch-like 2, Mayven (Drosophila)

Synonyms

ABP-KELCH; MAV; MAYVEN;

Species

Homo sapiens

Ensembl Protein

ENSP00000226725

InnateDB Gene

IDBG-43532 (KLHL2)

Protein Structure

UniProt Annotation

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269PubMed:15715669, ECO:0000269PubMed:23838290}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Detected throughout the brain. {ECO:0000269PubMed:10397770}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0016567

protein ubiquitination

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt