InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2

Summary

InnateDB Protein

IDBP-4356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2

Protein Name

B-cell CLL/lymphoma 2

Synonyms

Bcl-2; PPP1R50;

Species

Homo sapiens

Ensembl Protein

ENSP00000329623

InnateDB Gene

IDBG-4354 (BCL2)

Protein Structure

UniProt Annotation

Function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269PubMed:18570871}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:2250705}; Single-pass membrane protein {ECO:0000269PubMed:2250705}. Nucleus membrane {ECO:0000269PubMed:2250705}; Single-pass membrane protein {ECO:0000269PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269PubMed:2250705}; Single-pass membrane protein {ECO:0000269PubMed:2250705}.

Disease Associations

Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 196 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	196 [view]
Protein-Protein	179 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0015267	channel activity
GO:0016248	channel inhibitor activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0007565	female pregnancy
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314	response to radiation
GO:0009636	response to toxic substance
GO:0010039	response to iron ion
GO:0010507	negative regulation of autophagy
GO:0022898	regulation of transmembrane transporter activity
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032848	negative regulation of cellular pH reduction
GO:0034097	response to cytokine
GO:0035094	response to nicotine
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042100	B cell proliferation
GO:0042493	response to drug
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046902	regulation of mitochondrial membrane permeability
GO:0050853	B cell receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0051607	defense response to virus
GO:0051881	regulation of mitochondrial membrane potential
GO:0051902	negative regulation of mitochondrial depolarization
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000811	negative regulation of anoikis
GO:2001234	negative regulation of apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0046930	pore complex

Protein Structure and Domains

PDB ID

InterPro

IPR002475 Bcl2-like
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
IPR004725 Apoptosis regulator, Bcl-2/ BclX
IPR013278 Apoptosis regulator, Bcl-2
IPR013279 Apoptosis regulator, Bcl-X
IPR026298 Blc2 family

PFAM

PF02180
PF00452

PRINTS

PR01863
PR01864
PR01862

PIRSF

SMART

SM00265

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt