InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRIG1

Summary

InnateDB Protein

IDBP-43581.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRIG1

Protein Name

leucine-rich repeats and immunoglobulin-like domains 1

Synonyms

LIG-1; LIG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000373208

InnateDB Gene

IDBG-43579 (LRIG1)

Protein Structure

UniProt Annotation

Function

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269PubMed:15282549}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269PubMed:11414704}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11414704}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM