InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FXYD1

Summary

InnateDB Protein

IDBP-43588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FXYD1

Protein Name

FXYD domain containing ion transport regulator 1

Synonyms

PLM;

Species

Homo sapiens

Ensembl Protein

ENSP00000343314

InnateDB Gene

IDBG-730319 (FXYD1)

Protein Structure

UniProt Annotation

Function

May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005254	chloride channel activity
GO:0031404	chloride ion binding

Biological Process

GO:0006811	ion transport
GO:0006821	chloride transport
GO:0006936	muscle contraction
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport