InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPMT1

Summary

InnateDB Protein

IDBP-43609.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPMT1

Protein Name

protein tyrosine phosphatase, mitochondrial 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325882

InnateDB Gene

IDBG-43607 (PTPMT1)

Protein Structure

UniProt Annotation

Function

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}. Note=Associated with the inner membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008962	phosphatidylglycerophosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006644	phospholipid metabolic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0032049	cardiolipin biosynthetic process
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0046855	inositol phosphate dephosphorylation