InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD17B2

Summary

InnateDB Protein

IDBP-43857.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B2

Protein Name

hydroxysteroid (17-beta) dehydrogenase 2

Synonyms

EDH17B2; HSD17; SDR9C2;

Species

Homo sapiens

Ensembl Protein

ENSP00000199936

InnateDB Gene

IDBG-43855 (HSD17B2)

Protein Structure

UniProt Annotation

Function

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0032526	response to retinoic acid
GO:0055114	oxidation-reduction process