InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD22

Summary

InnateDB Protein

IDBP-44003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD22

Protein Name

CD22 molecule

Synonyms

SIGLEC-2; SIGLEC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000085219

InnateDB Gene

IDBG-44001 (CD22)

Protein Structure

UniProt Annotation

Function

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

B-lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20273