InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMRT3

Summary

InnateDB Protein

IDBP-44010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMRT3

Protein Name

doublesex and mab-3 related transcription factor 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000190165

InnateDB Gene

IDBG-44008 (DMRT3)

Protein Structure

UniProt Annotation

Function

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00070}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:10729223}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007548	sex differentiation
GO:0007628	adult walking behavior
GO:0019226	transmission of nerve impulse
GO:0021521	ventral spinal cord interneuron specification
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0046661	male sex differentiation