InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINB5

Summary

InnateDB Protein

IDBP-4413.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINB5

Protein Name

serpin peptidase inhibitor, clade B (ovalbumin), member 5

Synonyms

maspin; PI5;

Species

Homo sapiens

Ensembl Protein

ENSP00000372221

InnateDB Gene

IDBG-4411 (SERPINB5)

Protein Structure

UniProt Annotation

Function

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Normal mammary epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0006928	cellular component movement
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030198	extracellular matrix organization
GO:0050678	regulation of epithelial cell proliferation
GO:0060512	prostate gland morphogenesis