InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKRN1

Summary

InnateDB Protein

IDBP-44145.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKRN1

Protein Name

makorin ring finger protein 1

Synonyms

RNF61;

Species

Homo sapiens

Ensembl Protein

ENSP00000255977

InnateDB Gene

IDBG-44143 (MKRN1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269PubMed:16785614, ECO:0000269PubMed:19536131}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10843807, ECO:0000269PubMed:16785614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding