InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FFAR1

Summary

InnateDB Protein

IDBP-44148.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FFAR1

Protein Name

free fatty acid receptor 1

Synonyms

FFA1R; GPCR40; GPR40;

Species

Homo sapiens

Ensembl Protein

ENSP00000246553

InnateDB Gene

IDBG-44146 (FFAR1)

Protein Structure

UniProt Annotation

Function

Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000269PubMed:12496284}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed abundantly in pancreatic beta cells. {ECO:0000269PubMed:16289108}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0008289	lipid binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030073	insulin secretion
GO:0042593	glucose homeostasis
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR013312 G protein-coupled receptor 40-related receptor
IPR013313 GPR40 receptor fatty acid
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01904
PR01905

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14842