Version 5.4
Homo sapiens Protein: VPS16
Summary
InnateDB Protein IDBP-44171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS16
Protein Name vacuolar protein sorting 16 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369836
InnateDB Gene IDBG-229329 (VPS16)
Protein Structure
UniProt Annotation
Function May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.
Subcellular Localization Late endosome membrane {ECO:0000269PubMed:17897319}; Peripheral membrane protein {ECO:0000269PubMed:17897319}; Cytoplasmic side {ECO:0000269PubMed:17897319}. Lysosome membrane {ECO:0000269PubMed:17897319}; Peripheral membrane protein {ECO:0000269PubMed:17897319}; Cytoplasmic side {ECO:0000269PubMed:17897319}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR006925 Vps16, C-terminal
IPR006926 Vps16, N-terminal
PFAM PF04840
PF04841
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H269
PhosphoSite PhosphoSite-Q9H269
TrEMBL A1A4H0
UniProt Splice Variant
Entrez Gene 64601
UniGene
RefSeq NP_536338
HUGO HGNC:14584
OMIM 608550
CCDS CCDS13037
HPRD 12259
IMGT
EMBL AF308801 AK055787 AL161656 AL834401 BC012422 BC021291 BC064406 BC126431
GenPept AAG34678 AAH12422 AAH21291 AAH64406 AAI26432 BAB71013 CAC21465 CAD39063 CAI12120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca