InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS16

Summary

InnateDB Protein

IDBP-44173.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS16

Protein Name

vacuolar protein sorting 16 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369810

InnateDB Gene

IDBG-229329 (VPS16)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Subcellular Localization

Late endosome membrane {ECO:0000269PubMed:17897319}; Peripheral membrane protein {ECO:0000269PubMed:17897319}; Cytoplasmic side {ECO:0000269PubMed:17897319}. Lysosome membrane {ECO:0000269PubMed:17897319}; Peripheral membrane protein {ECO:0000269PubMed:17897319}; Cytoplasmic side {ECO:0000269PubMed:17897319}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0006886	intracellular protein transport
GO:0046718	viral entry into host cell

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005884	actin filament
GO:0030424	axon
GO:0030897	HOPS complex
GO:0031902	late endosome membrane
GO:0043025	neuronal cell body
GO:0055037	recycling endosome