InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGK

Summary

InnateDB Protein

IDBP-44454.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGK

Protein Name

acylglycerol kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347581

InnateDB Gene

IDBG-44452 (AGK)

Protein Structure

UniProt Annotation

Function

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. {ECO:0000269PubMed:15939762}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:15939762, ECO:0000269PubMed:16269826}.

Disease Associations

Mitochondrial DNA depletion syndrome 10 (MTDPS10) [MIM:212350]: An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. {ECO:0000269PubMed:22277967, ECO:0000269PubMed:22284826}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cataract 38 (CTRCT38) [MIM:614691]: An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269PubMed:22415731}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in muscle, heart, kidney and brain. {ECO:0000269PubMed:15939762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001727	lipid kinase activity
GO:0001729	ceramide kinase activity
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005524	ATP binding
GO:0047620	acylglycerol kinase activity

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0046486	glycerolipid metabolic process
GO:0046513	ceramide biosynthetic process
GO:0046834	lipid phosphorylation