Version 5.4
Homo sapiens Protein: SERPINB12
Summary
InnateDB Protein IDBP-4446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB12
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000269491
InnateDB Gene IDBG-4442 (SERPINB12)
Protein Structure
UniProt Annotation
Function Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0019899 enzyme binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0042177 negative regulation of protein catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P63
PhosphoSite PhosphoSite-
TrEMBL Q3SYB5
UniProt Splice Variant
Entrez Gene 89777
UniGene
RefSeq NP_536722
HUGO HGNC:14220
OMIM 615662
CCDS CCDS11984
HPRD 11548
IMGT
EMBL AF411191 BC103884
GenPept AAI03885 AAL05571

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca