InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STRN

Summary

InnateDB Protein

IDBP-44505.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRN

Protein Name

striatin, calmodulin binding protein

Synonyms

SG2NA;

Species

Homo sapiens

Ensembl Protein

ENSP00000368513

InnateDB Gene

IDBG-44499 (STRN)

Protein Structure

UniProt Annotation

Function

Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in brain. {ECO:0000269PubMed:9693043}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030331	estrogen receptor binding
GO:0032403	protein complex binding
GO:0051721	protein phosphatase 2A binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0007626	locomotory behavior
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0016358	dendrite development
GO:0070830	tight junction assembly

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005737	cytoplasm
GO:0005923	tight junction
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane