InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALNT7

Summary

InnateDB Protein

IDBP-44587.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT7

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265000

InnateDB Gene

IDBG-44585 (GALNT7)

Protein Structure

UniProt Annotation

Function

Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS. {ECO:0000269PubMed:10544240}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process