InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATXN3L

Summary

InnateDB Protein

IDBP-44593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATXN3L

Protein Name

ataxin 3-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369996

InnateDB Gene

IDBG-44591 (ATXN3L)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that cleaves both 'Lys-48'- linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0008242	omega peptidase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0016579	protein deubiquitination

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR003903 Ubiquitin interacting motif
IPR006155 Machado-Joseph disease protein MJD

PFAM

PF02809
PF02099

PRINTS

PR01233

PIRSF

SMART

SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H3M9

PhosphoSite

PhosphoSite-Q9H3M9

TrEMBL

UniProt Splice Variant

Entrez Gene

92552

UniGene

Hs.382641

RefSeq

NP_001129467

HUGO

HGNC:24173

OMIM

300920

CCDS

CCDS48080

HPRD

IMGT

EMBL

AB050195 AC004674 BC137186 BC137187 CH471074

GenPept

AAI37187 AAI37188 BAB18799 EAW98819