Homo sapiens Protein: SKP1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-44625.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | SKP1 | ||||||||||||||||||||||||
Protein Name | S-phase kinase-associated protein 1 | ||||||||||||||||||||||||
Synonyms | EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L; | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Protein | ENSP00000231487 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-44621 (SKP1) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2. {ECO:0000269PubMed:16209941, ECO:0000269PubMed:20181953, ECO:0000269PubMed:22113614, ECO:0000269PubMed:23431138}. | ||||||||||||||||||||||||
Subcellular Localization | |||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 280 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||
InterPro |
IPR001232
SKP1 component IPR011333 BTB/POZ fold IPR016072 SKP1 component, dimerisation IPR016073 SKP1 component, POZ domain IPR016897 E3 ubiquitin ligase, SCF complex, Skp subunit |
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PFAM |
PF01466
PF03931 |
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PRINTS | |||||||||||||||||||||||||
PIRSF |
PIRSF028729
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SMART |
SM00512
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TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | P63208 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P63208 | ||||||||||||||||||||||||
TrEMBL | E7ERH2 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 6500 | ||||||||||||||||||||||||
UniGene | Hs.733173 | ||||||||||||||||||||||||
RefSeq | NP_733779 | ||||||||||||||||||||||||
HUGO | HGNC:10899 | ||||||||||||||||||||||||
OMIM | 601434 | ||||||||||||||||||||||||
CCDS | CCDS4171 | ||||||||||||||||||||||||
HPRD | 03255 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AC011336 AC104109 BC009839 BC020798 BC025673 BC065730 CH471062 U33760 U37558 Z47087 | ||||||||||||||||||||||||
GenPept | AAA79202 AAC50241 AAH09839 AAH20798 AAH25673 AAH65730 CAA87392 EAW62270 EAW62271 EAW62272 EAW62276 | ||||||||||||||||||||||||