InnateDB Protein
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IDBP-44634.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FARP1
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Protein Name
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FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
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Synonyms
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CDEP; FARP1-IT1; PLEKHC2; PPP1R75;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365765
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InnateDB Gene
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IDBG-44626 (FARP1)
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Protein Structure
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Function |
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. {ECO:0000269PubMed:9425278}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005089
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Rho guanyl-nucleotide exchange factor activity
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GO:0008092
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cytoskeletal protein binding
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GO:0030676
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Rac guanyl-nucleotide exchange factor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4F1
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PhosphoSite |
PhosphoSite-Q9Y4F1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10160
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UniGene |
Hs.734787
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RefSeq |
NP_001001715
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HUGO |
HGNC:3591
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OMIM |
602654
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CCDS |
CCDS32000
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HPRD |
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IMGT |
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EMBL |
AB008430
AL136300
AL137249
AL161896
AL445223
BC041595
BC065020
BC071592
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GenPept |
AAH41595
AAH71592
BAA24267
CAI10952
CAI10953
CAI12946
CAI15981
CAI39458
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