Version 5.4
Homo sapiens Protein: COTL1
Summary
InnateDB Protein IDBP-44683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COTL1
Protein Name coactosin-like 1 (Dictyostelium)
Synonyms CLP;
Species Homo sapiens
Ensembl Protein ENSP00000262428
InnateDB Gene IDBG-44681 (COTL1)
Protein Structure
UniProt Annotation
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269PubMed:11583571, ECO:0000269PubMed:19807693}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269PubMed:11583571}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0008150 biological_process
GO:0050832 defense response to fungus
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002108 Actin-depolymerising factor homology domain
PFAM PF00241
PRINTS
PIRSF
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14019
PhosphoSite PhosphoSite-Q14019
TrEMBL H3BT58
UniProt Splice Variant
Entrez Gene 23406
UniGene Hs.710668
RefSeq NP_066972
HUGO HGNC:18304
OMIM 606748
CCDS CCDS10947
HPRD 09482
IMGT
EMBL AC022165 AC092145 AK315675 BC010039 BC010884 BC016702 BC042970 BC053682 BT006968 CH471114 L54057
GenPept AAA88022 AAH10039 AAH10884 AAH16702 AAH42970 AAH53682 AAP35614 BAG38040 EAW95476 EAW95477

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca