Version 5.4
Homo sapiens Protein: SHQ1
Summary
InnateDB Protein IDBP-44822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHQ1
Protein Name SHQ1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315182
InnateDB Gene IDBG-44820 (SHQ1)
Protein Structure
UniProt Annotation
Function Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000269PubMed:19383767}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:19383767}. Nucleus, nucleoplasm {ECO:0000269PubMed:19383767}. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0022618 ribonucleoprotein complex assembly
GO:0043065 positive regulation of apoptotic process
GO:2000233 negative regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007009 SHQ1 protein
IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04925
PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PI26
PhosphoSite PhosphoSite-Q6PI26
TrEMBL C9J6N3
UniProt Splice Variant
Entrez Gene 55164
UniGene Hs.714543
RefSeq NP_060600
HUGO HGNC:25543
OMIM 613663
CCDS CCDS33788
HPRD 07682
IMGT
EMBL AC114876 AC134050 AK001401 AK024656 BC017204 BC017274 BC025270 BC032671 BC039830 BC047879 BX641074 CH471055
GenPept AAH17204 AAH17274 AAH25270 AAH32671 AAH39830 AAH47879 BAA91669 BAB14947 CAE46037 EAW65521 EAW65523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca