InnateDB Protein
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IDBP-4484.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKAP6
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Protein Name
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A kinase (PRKA) anchor protein 6
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Synonyms
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ADAP100; ADAP6; AKAP100; mAKAP; PRKA6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000280979
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InnateDB Gene
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IDBG-4482 (AKAP6)
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Protein Structure
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Function |
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
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Subcellular Localization |
Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
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Disease Associations |
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Tissue Specificity |
Highly expressed in cardiac and skeletal muscle, followed by brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001508
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action potential
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GO:0006605
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protein targeting
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GO:0010738
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regulation of protein kinase A signaling
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GO:0010880
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regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
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GO:0019933
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cAMP-mediated signaling
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GO:0030307
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positive regulation of cell growth
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GO:0030818
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negative regulation of cAMP biosynthetic process
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GO:0032514
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positive regulation of protein phosphatase type 2B activity
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GO:0051281
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positive regulation of release of sequestered calcium ion into cytosol
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GO:0051533
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positive regulation of NFAT protein import into nucleus
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GO:0060306
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regulation of membrane repolarization
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GO:0060316
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positive regulation of ryanodine-sensitive calcium-release channel activity
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GO:0061051
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positive regulation of cell growth involved in cardiac muscle cell development
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GO:0070886
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positive regulation of calcineurin-NFAT signaling cascade
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GO:0071320
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cellular response to cAMP
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GO:0071345
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cellular response to cytokine stimulus
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GO:1901381
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positive regulation of potassium ion transmembrane transport
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GO:1902261
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positive regulation of delayed rectifier potassium channel activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR018159
Spectrin/alpha-actinin
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00150
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TIGRFAMs |
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Modification |
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SwissProt |
Q13023
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PhosphoSite |
PhosphoSite-Q13023
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TrEMBL |
G3V569
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UniProt Splice Variant |
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Entrez Gene |
9472
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UniGene |
Hs.509083
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RefSeq |
NP_004265
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HUGO |
HGNC:376
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OMIM |
604691
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CCDS |
CCDS9644
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HPRD |
05257
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IMGT |
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EMBL |
AB002309
AL049781
AL117672
AL132988
AL136298
BC150185
BC150288
BC154413
CH471078
U17195
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GenPept |
AAA92354
AAI50186
AAI50289
AAI54414
BAA20770
EAW65931
EAW65932
EAW65933
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