InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINB3

Summary

InnateDB Protein

IDBP-4492.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINB3

Protein Name

serpin peptidase inhibitor, clade B (ovalbumin), member 3

Synonyms

HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000329498

InnateDB Gene

IDBG-4488 (SERPINB3)

Protein Structure

UniProt Annotation

Function

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269PubMed:19166818}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10956412, ECO:0000269PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Disease Associations

Tissue Specificity

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269PubMed:14970861}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0009615	response to virus
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0043086	negative regulation of catalytic activity
GO:0045861	negative regulation of proteolysis