InnateDB Protein
|
IDBP-44953.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ZDHHC7
|
Protein Name
|
zinc finger, DHHC-type containing 7
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000315604
|
InnateDB Gene
|
IDBG-44951 (ZDHHC7)
|
Protein Structure
|
|
Function |
Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. {ECO:0000250, ECO:0000269PubMed:22031296}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269PubMed:22031296}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
|
Protein-Protein |
16
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001594
Zinc finger, DHHC-type, palmitoyltransferase
|
PFAM |
PF01529
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NXF8
|
PhosphoSite |
PhosphoSite-Q9NXF8
|
TrEMBL |
H3BNQ9
|
UniProt Splice Variant |
|
Entrez Gene |
55625
|
UniGene |
Hs.734672
|
RefSeq |
NP_060210
|
HUGO |
HGNC:18459
|
OMIM |
614604
|
CCDS |
CCDS10950
|
HPRD |
15722
|
IMGT |
|
EMBL |
AC092341
AK000286
AK001654
BC017702
BC018772
CH471114
|
GenPept |
AAH17702
AAH18772
BAA91055
BAA91814
EAW95464
EAW95465
|
|
|