Version 5.4
Homo sapiens Protein: GLRA3
Summary
InnateDB Protein IDBP-45030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRA3
Protein Name glycine receptor, alpha 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274093
InnateDB Gene IDBG-45026 (GLRA3)
Protein Structure
UniProt Annotation
Function The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Widely distributed throughout the central nervous system.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellular-glycine-gated chloride channel activity
GO:0022824 transmitter-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha
IPR008130 Glycine receptor alpha3
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01673
PR01676
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75311
PhosphoSite PhosphoSite-O75311
TrEMBL Q9UPF3
UniProt Splice Variant
Entrez Gene 8001
UniGene Hs.710910
RefSeq NP_006520
HUGO HGNC:4328
OMIM 600421
CCDS CCDS3822
HPRD 02688
IMGT
EMBL AC131948 AF017715 AF017716 AF017717 AF017718 AF017719 AF017720 AF017721 AF017722 AF017723 AF017724 AF018157 BC036086 CH471056 U93917
GenPept AAC39917 AAC39918 AAC39919 AAH36086 AAY40916 EAX04730 EAX04732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca