InnateDB Protein
|
IDBP-4507.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RNF185
|
Protein Name
|
ring finger protein 185
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000320508
|
InnateDB Gene
|
IDBG-4505 (RNF185)
|
Protein Structure
|
|
Function |
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. {ECO:0000269PubMed:21931693, ECO:0000269PubMed:24019521}.
|
Subcellular Localization |
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
49
[view]
|
Protein-Protein |
49
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
|
PFAM |
PF13639
PF14634
PF00097
|
PRINTS |
|
PIRSF |
|
SMART |
SM00184
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96GF1
|
PhosphoSite |
PhosphoSite-Q96GF1
|
TrEMBL |
A0A024R1F5
|
UniProt Splice Variant |
|
Entrez Gene |
91445
|
UniGene |
Hs.570733
|
RefSeq |
NP_689480
|
HUGO |
HGNC:26783
|
OMIM |
|
CCDS |
CCDS13890
|
HPRD |
08790
|
IMGT |
|
EMBL |
AC002073
AC005005
AK095947
AK291236
BC009504
BC012817
BC026040
BC033166
BC035684
CH471095
CR456349
DQ296559
DQ296561
DQ296562
DQ296565
|
GenPept |
AAH09504
AAH12817
AAH26040
AAH33166
AAH35684
ABB97506
ABB97508
ABB97509
ABB97512
BAC04659
BAF83925
CAG30235
EAW59947
EAW59949
EAW59951
|
|
|