InnateDB Protein
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IDBP-45080.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRSS1
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Protein Name
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protease, serine, 1 (trypsin 1)
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Synonyms
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TRP1; TRY1; TRY4; TRYP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000308720
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InnateDB Gene
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IDBG-45037 (PRSS1)
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Protein Structure
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Function |
Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. {ECO:0000269PubMed:7945238}.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269PubMed:10204851, ECO:0000269PubMed:10381903, ECO:0000269PubMed:10930381, ECO:0000269PubMed:11073545, ECO:0000269PubMed:11788572, ECO:0000269PubMed:11866271, ECO:0000269PubMed:14695529, ECO:0000269PubMed:15776435, ECO:0000269PubMed:8841182, ECO:0000269PubMed:9322498, ECO:0000269PubMed:9633818}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
P07477
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PhosphoSite |
PhosphoSite-P07477
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TrEMBL |
Q7Z445
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UniProt Splice Variant |
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Entrez Gene |
5644
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UniGene |
Hs.722430
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RefSeq |
NP_002760
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HUGO |
HGNC:9475
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OMIM |
276000
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CCDS |
CCDS5872
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HPRD |
02039
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IMGT |
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EMBL |
AC231380
AF314534
AF315309
AF315310
AF315311
AK312199
AY254094
AY254095
BC128226
CH236959
CH471198
L36092
M22612
U70137
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GenPept |
AAA61231
AAC50728
AAC80207
AAG30943
AAG30947
AAG30948
AAG30949
AAI28227
AAP42827
AAP42828
BAG35132
EAL23773
EAW51925
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