Version 5.4
Homo sapiens Protein: GNRH2
Summary
InnateDB Protein IDBP-45148.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNRH2
Protein Name gonadotropin-releasing hormone 2
Synonyms GnRH-II; LH-RHII;
Species Homo sapiens
Ensembl Protein ENSP00000369704
InnateDB Gene IDBG-45138 (GNRH2)
Protein Structure
UniProt Annotation
Function Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002012 Gonadotropin-releasing hormone
PFAM PF00446
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43555
PhosphoSite PhosphoSite-O43555
TrEMBL
UniProt Splice Variant
Entrez Gene 2797
UniGene
RefSeq NP_847902
HUGO HGNC:4420
OMIM 602352
CCDS CCDS13042
HPRD 03830
IMGT
EMBL AF036329 AF036330 AL121905 BC069362 BC115399 BC115400 CH471133
GenPept AAC02980 AAC02981 AAH69362 AAI15400 AAI15401 CAC10338 CAC29100 CAC29101 EAX10559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca