InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPV6

Summary

InnateDB Protein

IDBP-45162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV6

Protein Name

transient receptor potential cation channel, subfamily V, member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352358

InnateDB Gene

IDBG-45160 (TRPV6)

Protein Structure

UniProt Annotation

Function

Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. {ECO:0000269PubMed:11097838, ECO:0000269PubMed:11278579}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR005821 Ion transport domain
IPR008344 Transient receptor potential cation channel subfamily V member 5/6
IPR008345 Transient receptor potential channel, vanilloid 6
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF11929
PF12796

PRINTS

PR01415
PR01765
PR01766

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt