InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXDC1

Summary

InnateDB Protein

IDBP-45220.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXDC1

Protein Name

plexin domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323927

InnateDB Gene

IDBG-45218 (PLXDC1)

Protein Structure

UniProt Annotation

Function

Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.Isoform 2: Secreted {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. {ECO:0000269PubMed:10947988, ECO:0000269PubMed:11559528, ECO:0000269PubMed:17560052, ECO:0000269PubMed:18316703}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0007275	multicellular organismal development
GO:0021510	spinal cord development

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043235	receptor complex