InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIMK2

Summary

InnateDB Protein

IDBP-4524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMK2

Protein Name

LIM domain kinase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339916

InnateDB Gene

IDBG-4518 (LIMK2)

Protein Structure

UniProt Annotation

Function

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. {ECO:0000269PubMed:10436159, ECO:0000269PubMed:11018042}.

Subcellular Localization

Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus.Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.

Disease Associations

Tissue Specificity

Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. {ECO:0000269PubMed:8954941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0042325	regulation of phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005801	cis-Golgi network

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001478 PDZ domain
IPR001781 Zinc finger, LIM-type
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008025 PKC-activated phosphatase-1 inhibitor
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00595
PF13180
PF00412
PF05361

PRINTS

PR00109

PIRSF

SMART

SM00228
SM00132
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt