InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPV5

Summary

InnateDB Protein

IDBP-45286.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPV5

Protein Name

transient receptor potential cation channel, subfamily V, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265310

InnateDB Gene

IDBG-45284 (TRPV5)

Protein Structure

UniProt Annotation

Function

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:18768590}; Multi-pass membrane protein {ECO:0000269PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269PubMed:10945469, ECO:0000269PubMed:11549322}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0034220	ion transmembrane transport
GO:0051262	protein tetramerization
GO:0055085	transmembrane transport
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR008344 Transient receptor potential cation channel subfamily V member 5/6
IPR008346 Transient receptor potential cation channel subfamily V member 5
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415
PR01765
PR01767

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt